Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division

•HSC functions are inversely correlated with their divisional history.•Mitochondria remodeling occurs in HSCs throughout the cell cycle.•Mitochondria-driven metabolic adaptation drives HSC functional decline.•Mitochondria-driven may keep memory. Hematopoietic stem cells (HSCs) characterized by ability to produce all of blood and immune system have been used for transplantation decades. Although regenerative potential is high, self-renewal limited. history. Recent advances our understanding regulation through division suggest that never replicate into identical self, but rather progeny gradually lose functionality at each round division. accompanied major transcriptional changes. In this perspective, possibility mitochondrial metabolism confers memory programs extinction discussed. Adult hematopoietic apex cells. Being multipotent, give rise lineages. long-lived reside mostly a quiescent state. 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